Harlan 啮齿动物饲料 Rodent diets
Harlan Teklad动物饲料
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Rodent diets
As a researcher, you want to have as much control as possible over what goes into your study animals. At Envigo, we understand that. That is why we developed Teklad Global Rodent Diets® .
Teklad Global Rodent Diets® are a special integrated range of vegetarian laboratory rodent diets developed to be nutritionally complete for various life stages from breeding through long-term maintenance. Global rodent laboratory diets contain levels of protein, energy, vitamins and minerals that are more appropriate to the needs of modern biomedical research studies.
作为一名研究人员，您希望尽可能多地控制进入您的研究动物的内容。 在 Envigo，我们明白这一点。 这就是我们开发 Teklad Global Rodent Diets® 的原因。
Teklad Global Rodent Diets® 是一种特殊的综合素食实验室啮齿动物饮食系列，旨在为从繁殖到长期维持的各个生命阶段提供营养完整的食物。 全球啮齿动物实验室饮食含有更适合现代生物医学研究需求的蛋白质、能量、维生素和矿物质水平。
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Furthermore, in global rodent diets particular attention has been placed on avoiding, as far as practical, ingredients that are reported to have adverse confounding effects on experimental results. This has resulted in a range of Teklad rodent laboratory diets that contain:
- No fish meal
- No meat meals or meat by-products
- No alfalfa meal
- No soybean meal or reduced levels
- No animal fat
By excluding animal by-products, the presence of nitrosamines (a potential carcinogen) is avoided. Exclusion of alfalfa meal reduces chlorophyll, improving optical imaging clarity. Reduction or removal of soybean meal, together with elimination of alfalfa meal, minimizes levels of naturally-occurring phytoestrogens. Phytoestrogens interact with endogenous estrogens and potentially can affect studies in many research areas. Read more about this in these pieces:
- Dietary phytoestrogens, a source of research variation
Ask a nutritionist series: Impact of phytoestrogens on research, Volume 1 - Phytoestrogens limit translation of preclinical results to clinical outcomes
Ask a nutritionist series: Impact of phytoestrogens on research, Volume 2
通过排除动物副产品，避免了亚硝胺（一种潜在的致癌物质）的存在。 苜蓿粉的排除减少了叶绿素，提高了光学成像的清晰度。 减少或去除豆粕，同时去除苜蓿粉，可以最大限度地减少天然植物雌激素的含量。 植物雌激素与内源性雌激素相互作用，并可能影响许多研究领域的研究。 在这些文章中阅读更多相关信息：
膳食植物雌激素，研究变化的来源
询问营养师系列：植物雌激素对研究的影响，第 1 卷
植物雌激素限制了将临床前结果转化为临床结果
询问营养师系列：植物雌激素对研究的影响，第 2 卷
Products
| Teklad rodent diets | Non-autoclavable form | Autoclavable | Irradiated |
|---|---|---|---|
| Teklad global 14% protein | 2014, 2014C | 2914 | |
| Teklad global 16% protein | 2016, 2016C | 2916 | |
| Teklad global 18% protein | 2018, 2018C | 2018S, 2018SX | 2918 |
| Teklad global 19% protein extruded | 2019 | 2019S | 2919 |
| Teklad global soy protein-free extruded | 2020X | 2020SX | 2920X |
| Traditional diets | see more | see more | see more |
Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.
Traditional rodent diets were formulated decades ago based on understanding of rodent nutrition, ingredients, and diet manufacturing at the time. While traditional diets will supply the known nutrient needs of your laboratory animals, we recommend you consider the use of a diet from our newer global diet line for your modern research needs.
Teklad Global Rodent Diets® are modern formulas designed to reduce research variables. Specifically, these diets contain more appropriate nutrient levels, and limit or exclude ingredients that are reported to have effects on a wide variety of research endpoints.
- Lower, more appropriate protein levels can improve survival and reduce morbidity
- Vegetarian with no nitrosamines (a potential carcinogen)
- Formulated to exclude alfalfa meal, greatly improving fluorescent imaging clarity
- Formulated to exclude or lower soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
- Extruded rodent diets dramatically reduce clumping and hardness after autoclaving (2018SX , 2019S , 2020SX ), and in general result in less diet waste and cleaner cages
Teklad rodent diets are natural-ingredient diets specifically formulated to provide the proper balance of all known nutrients considered essential for the growth, maintenance, and reproduction of rats, mice, gerbils and hamsters. These diets conform to the nutrient requirements for rodents established by the National Research Council (1995).
Teklad rodent diets provide uniform nutrition. They are fixed-formula diets designed to minimize the nutrient variances which otherwise could occur if the ingredient composition of a diet were altered from one batch to the next.
Protein is supplied primarily by plant sources. Supplemental amino acids are added to provide the proper amount and balance of essential amino acids. All rodent diets are fortified with vitamins and minerals to help support the regulation of body fluids and the proper functioning of body systems to ensure the adequate growth, maintenance, and reproduction of research rodents. Autoclavable diets are supplemented with additional vitamins to compensate for losses that occur during autoclaving. Since our diets are nutritionally complete and balanced, it is not necessary to add dietary supplements.
There is no definitive point where one is able to predict when a specific diet will spoil or become deficient in one or more nutrients. The common guideline of a six month shelf life is based on longstanding practice in North America. In Europe and Asia, differences in local practices and regulatory oversight have led to Teklad standard natural ingredient diets being routinely used out to nine months and sometimes 12 months post-manufacture. This practical experience, along with literature support and vitamin testing over time, gives us confidence that these diets continue to support animal health and study integrity out to at least nine months post-manufacture. Please refer to your institution for guidance if you are unsure of local policies.
Recommended storage conditions:
- Cool and dry; at or below 70 degrees fahrenheit with humidity ideally below 50%, but up to 65% is acceptable
- Clean and free of pests
- In original packaging or in a container that prevents continuous exposure to light and minimal exposure to air
Standard natural ingredient rodent diets are complete diets for rats, mice, gerbils and hamsters, that should be allowed ad libitum access to the diet. Fresh water should be available at all times.
并非所有产品都在当地备货；可能需要延长交货时间和额外费用。
许多饮食都可以通过产品代码后面的“C”指定的认证格式获得。当日粮获得认证时，会针对一组污染物对代表性样本进行测试。如果库存没有经过认证，可根据要求提供认证。最小订单量和额外费用可能适用。
传统的啮齿动物饮食是几十年前基于对当时啮齿动物营养、成分和饮食制造的了解而制定的。虽然传统饮食将满足您的实验动物已知的营养需求，但我们建议您考虑使用我们更新的全球饮食系列中的饮食来满足您的现代研究需求。
Teklad Global Rodent Diets® 是现代配方，旨在减少研究变量。具体来说，这些饮食含有更适当的营养水平，并限制或排除据报道对各种研究终点有影响的成分。
更低、更合适的蛋白质水平可以提高生存率并降低发病率
不含亚硝胺（潜在致癌物）的素食主义者
配方可排除苜蓿粉，大大提高荧光成像清晰度
配方可排除或减少豆粕，从而最大限度地减少异黄酮的存在，异黄酮是实验室动物饮食中发现的主要植物雌激素类型
膨化啮齿动物饲料可显着减少高压灭菌后的结块和硬度（2018SX、2019S、2020SX），通常会减少饲料浪费和清洁笼子
Teklad 啮齿动物饲料是一种天然成分的饲料，专门配制用于提供所有已知营养素的适当平衡，这些营养素被认为对大鼠、小鼠、沙鼠和仓鼠的生长、维持和繁殖至关重要。这些饮食符合国家研究委员会 (1995) 制定的啮齿动物的营养需求。
Teklad 啮齿动物饮食提供均匀的营养。它们是固定配方的饮食，旨在最大限度地减少营养差异，否则如果饮食的成分组成从一批更改为下一批，则可能发生这种情况。
蛋白质主要由植物来源提供。添加补充氨基酸以提供适量和平衡的必需氨基酸。所有啮齿动物的饮食都含有维生素和矿物质，以帮助支持体液的调节和身体系统的正常运作，以确保研究啮齿动物的充分生长、维持和繁殖。可高压灭菌的饮食补充了额外的维生素，以补偿高压灭菌期间发生的损失。由于我们的饮食营养完整且均衡，因此没有必要添加膳食补充剂。
没有明确的点可以预测特定饮食何时会变质或缺乏一种或多种营养素。六个月保质期的通用准则基于北美的长期实践。在欧洲和亚洲，当地实践和监管监督的差异导致 Teklad 标准天然成分饮食通常在生产后 9 个月，有时甚至 12 个月内使用。这种实践经验，加上文献支持和维生素测试，让我们相信这些饮食在生产后至少 9 个月内继续支持动物健康和研究完整性。如果您不确定当地政策，请咨询您的机构以获得指导。
推荐的储存条件：
凉爽干燥；在华氏 70 度或以下，湿度理想地低于 50%，但最高 65% 是可以接受的
干净无害虫
在原包装或容器中，以防止持续暴露在光线下并尽量减少暴露在空气中
标准的天然成分啮齿动物饮食是大鼠、小鼠、沙鼠和仓鼠的完整饮食，应允许随意获取饮食。淡水应随时可用。
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