Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt 去氢表雄酮硫酸钠


描述

Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt

去氢表雄酮硫酸钠

产品关键词

DHEAS; Dehydroepiandrosterone (DHEA)去氢表雄酮;Androstenolone sulfate 雄甾烯二酮;GABAA受体调节剂;Neurosteroid神经类固醇;CAS NO:1099-87-2;

产品信息

产品名称

产品编号

规格

价格(元

Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt去氢表雄酮硫酸钠   

MZ10051-50MG

50mg

399

     MZ10051-100MG      

100mg     

689

MZ10051-1G

1g

3429

产品描述

去氢表雄酮硫酸钠(Dehydroepiandrosterone Sulfate Sodium Salt, DHEAS)是去氢表雄酮(DHEA)的代谢物,后者是肾上腺的主要分泌物和人体用于合成活性类固醇激素(甾体激素)的主导循环前体。青少年体内DHEAS正常的循环浓度约10µM,某些肾上腺素皮质紊乱会急剧增高。

产品特性

1)CAS NO:1099-87-2
2)化学名:sodium (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl sulfate
3)同义名:Dehydroepiandrosterone Sulfate (sodium salt); DHEAS; DHA-S; NSC 72822; Sodium prasterone sulfate; Dehydroepiandrosterone-3-sulfate Sodium Salt; Sodium Dehydroepiandrosterone-3-sulfate; 脱氢表雄酮硫酸钠;硫酸普拉酮钠;硫酸普拉睾酮钠;脱氢表雄甾酮-3-硫酸钠;
4)分子式:C19H27NaO5S
5) 分子量:390.47 g/mol
6) 外观:白色至类白色粉末
7) 纯度:≥98%
8) 溶解性:溶于乙醇(~2mg/ml)、DMSO(~30mg/ml)、DMF(~30mg/ml)
9) 化学结构式:

保存与运输方法

保存:2-8℃干燥保存,2年有效;-20℃干燥保存,3年有效。

运输:常温运输。

注意事项

1)本品不是临床药物,只能用于科研用途,不能用于诊断或临床用途。
2)为了您的安全和健康,请穿实验服并戴一次性手套操作。

储存液制备

使用方法【源自文献,仅作参考】

文献1,Yoon SY et al. Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABAA receptors. Br J Pharmacol. 2009 Jun;157(4):666-73.PMID: 19422393

体内研究(动物模型):

动物模型(Animal Model):Male ICR mice (24–30 g)

药物配制(Preparation):DHEA and progesterone were diluted in 1% DMSO in corn oil. DHEAS was diluted in 1% DMSO in saline.

给药剂量(Dosage):Drugs were dissolved in 5 µL of vehicle.Intrathecal injections (5 µL volume) were made into the L5-L6 intervertebral space of unanaesthetized mice using a 10 µL Hamilton syringe connected to a 30-gauge needle. The control group received an i.t. injection of vehicle.

目的与结果(Results):To study the effect of DHEASand DHEAon the nociceptive threshold to mechanical stimulation.i.t. injection of DHEAS (150, 300 or 600 pmol) dose-dependently decreased withdrawal threshold to mechanical stimulation compared with that of the vehicle control group. Conversely,i.t. injection of DHEA (0.1, 10 and 1000 nmol per mouse)had no effect on the mechanical nociceptive threshold, even at the highest dose.

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MZ10051-50MG      

Dehydroepiandrosterone Sulfate (DHEAS) Sodium Salt去氢表雄酮硫酸钠      

50mg