抗体/试剂/诊断抗体原料,MouseAnti-human IL-6抗体

发表于由

品牌：Bioss/博奥森 | 货号：V0401-100ug

产品编号 V0401
英文名称 human IL-6
中文名称 人白介素6单克隆抗体
别    名 Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN.  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  生长因子和激素  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 6F5K
交叉反应 (predicted: Human, )
产品应用 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 23kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 ≥1mg/ml
免 疫 原 Recombinant human IL-6 (C-6x His-Tag)  
亚    型 IgG1
纯化方法 affinity purified by Protein G
缓 冲 液 0.01M PBS(pH7.4) with 0.1% Proclin300.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.

Function:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

Subcellular Location:
Secreted.

Post-translational modifications:
N- and O-glycosylated.

DISEASE:
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Similarity:
Belongs to the IL-6 superfamily.

SWISS:
P05231

Gene ID:
3569

Database links:

Entrez Gene: 3569 Human

Entrez Gene: 16193 Mouse

Entrez Gene: 24498 Rat

Omim: 147620 Human

SwissProt: P05231 Human

SwissProt: P08505 Mouse

SwissProt: P20607 Rat

Unigene: 654458 Human

Unigene: 1019 Mouse

Unigene: 9873 Rat

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