品牌：Bioss/博奥森 | 货号：JP-017-10ug
产品编号
JP-017
产品分类
重组蛋白
英文名称
Recombinant human IL-2 protein (Active, HEK293)
中文名称
重组人白介素2 (活性的, Tag free)
英文别名
Interleukin-2; Interleukin 2; Interleukin2; rhIL-2; T-cell growth factor; T Cell Growth Factor; Aldesleukin; IL 2; IL2; Lymphokine; POIL2; T Cell Growth Factor; TCGF; Involved in regulation of T cell clonal expansion; IL2_HUMAN. ;Recombinant human IL-2 protein (Active, HEK293)
中文别名
人白介素2重组蛋白; 重组人白介素2; 人重组白介素2; 重组人白介素2（IL-2）;
蛋白细胞定位
分泌型蛋白
纯化方法
AC
理论分子量
15kDa
检测分子量
17 kDa
GeneID
3558
Swiss
P60568
浓度
＞0.5 mg/ml
储存液
Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization.
保存条件
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -80℃ under sterile conditions after reconstitution.
Subunit
Subcellular Location
Secreted.
DISEASE
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Similarity
Belongs to the IL-2 family.
Database links
Entrez Gene: 3558 Human
Entrez Gene: 16183 Mouse
Entrez Gene: 116562 Rat
Omim: 147680 Human
SwissProt: P60568 Human
SwissProt: P04351 Mouse
SwissProt: P17108 Rat
Unigene: 89679 Human
Unigene: 14190 Mouse
Unigene: 9871 Rat
背景资料
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
多肽活性
Yes
蛋白质与多肽-多肽序列
21-153/153
小分子偶联蛋白-蛋白载体
标签
Tag free
纯度
>95% as determined by SDS-PAGE
内毒素
<0.5 EU/μg as determined by LAL.
重组蛋白-表达系统
HEK293 cell
复溶
Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
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