Aldeyde-PEG是一种胺反应性PEG衍生物，可通过可用的胺基来修饰生物分子。醛基与赖氨酸残基的ε-胺和N端的α-胺之间的反应生成中间席夫碱。进一步用氢化物还原将形成稳定的C-N键。聚乙二醇醛在pH值为5.5至9.5时与胺基反应。较高的pH值将导致末端和赖氨酸基团的多重聚乙二醇化。醛-PEG是蛋白质或肽n端聚乙二醇化的常用PEG试剂。

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.