TDB–FITC-dextran

CAS number: 60842-46-8

FITC-dextran is supplied as a yellow/orange powder which dissolves

freely in water or salt solutions giving a yellow solution. FITC-dextrans

are primarily used for studying permeability and transport in cells

and tissues.

Spectral data: Excitation is best performed at 493 nm and

fluorescence measured at 518 nm.

Antonia Red™ products

Antonia Red™-dextrans
Antonia Red™-lysine-dextra

ATTO™-derivatives

ATTO488™-dextran
ATTO488™-lysine-dextran
ATTO647N™-lysine-dextran

FITC-derivatives

FITC-dextran
FITC -lysine-dextran
FITC-CM-dextran
FITC-CM-polysucrose
FITC-DEAE-dextran
FITC-DEAE-polysucrose
FITC-dextran sulfate
FITC-hydroxyethyl starch
FITC-inulin
FITC-polysucrose
FITC-Q-dextran
FITC-trehalose
Fluorescein Hyaluronic Acid

TRITC-derivatives

Tetramethylrhodamine Hyaluronic Acid
TRITC-lysine-dextran
TRITC-dextran
TRITC-polysurose

FITC -dextran

CAS Number: 60842-46-8

Fluorescein isothiocyanate (FITC)-dextrans are synthesised by coupling fluoresceinyl isothiocyanate (5-isomer) to selected dextran fractions. All batches are checked for molecular weight, degree of substitution, loss on drying and free FITC. TdB Labs produce FITC-dextrans from 4 kDa to 2000 kDa. FITC-dextrans are supplied as a yellow to orange powder.

Can’t find what you are looking for? We can always produce a customised product for you. Read more here.

If you need larger quantities, please contact us for a bulk quotation.

Structure
Dextran is a branched polysaccharide elaborated by the bacteria Leuconostoc mesenteroides B512F. Dextran is essentially a linear glucose chain linked by α-D-(1 – 6) linkages. The degree of branching is about 5 %. The fluorescein moiety is attached by a stable thiocarbamoyl linkage and the labelling procedure does not lead to any depolymerization of the dextran. FITC-dextrans have from 0.002-0.008 mol FITC per glucose unit. These low levels of substitution confer minimal charges to dextran, which is an essential requirement for permeability studies.

Spectral data
FITC-dextran has an excitation maximum of 493 nm and an emission maximum of 518 nm. Maximal intensity is observed at pH >8.

Storage and stability
FITC-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature. Studies at 37°C in rabbit plasma, muscle homogenate, liver homogenate and urine established that FITC-dextran is stable for at least 3 days. No changes in the molecular weight and no release of fluorescein moieties was noted (1).

Solubility
FITC-dextran dissolves readily in water.

Application
FITC-dextran is mainly used for studying permeability and microcirculation. It can also be used as a molecular size marker, for studies of drug delivery and more. Read more about applications here. FITC-dextrans are also very sensitive to the pH of their environment and they can be utilized as pH-indicators Read more about pH indicators here.

Catalog no	Name	MW (Da)	Packsize
FD4	FITC-dextran 4	4000	100mg
FD4	FITC-dextran 4	4000	1g
FD4	FITC-dextran 4	4000	5g
FD10	FITC-dextran 10	10000	100mg
FD10	FITC-dextran 10	10000	1g
FD10	FITC-dextran 10	10000	5g
FD20	FITC-dextran 20	20000	100mg
FD20	FITC-dextran 20	20000	1g
FD20	FITC-dextran 20	20000	5g
FD40	FITC-dextran 40	40000	100mg
FD40	FITC-dextran 40	40000	1g
FD40	FITC-dextran 40	70000	5g
FD70	FITC-dextran 70	70000	100mg
FD70	FITC-dextran 70	70000	1g
FD70	FITC-dextran 70	110000	5g
FD110	FITC-dextran 110	110000	100mg
FD110	FITC-dextran 110	110000	1g
FD110	FITC-dextran 110	150000	5g
FD150	FITC-dextran 150	150000	100mg
FD150	FITC-dextran 150	150000	1g
FD150	FITC-dextran 150	500000	5g
FD500	FITC-dextran 500	500000	100mg
FD500	FITC-dextran 500	500000	1g
FD500	FITC-dextran 500	500000	5g
FD2000	FITC-dextran 2000	2000000	100mg
FD2000	FITC-dextran 2000	2000000	1g
FD2000	FITC-dextran 2000	2000000	5g

References

All publications

Hagemann, F., Adametz, P., Wessling, M. & Thom, V. Modeling hindered diffusion of antibodies in agarose beads considering pore size reduction due to adsorption. Journal of Chromatography A 1626, 461319 (2020).
Ramirez, L.M.F., Gobin, E., Aid-Launais, R., Journe, C., Moraes, F.C., Picton, L., Cerf, D.L., Letourneur, D., Chauvierre, C., Chaubet, F.
Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets. Carbohydrate Polymers (2020) doi: https://doi.org/10.1016/j.carbpol.2020.116457.
Hutton, A. R. J., McCrudden, M. T. C., Larrañeta, E. & Donnelly, R. F. Influence of molecular weight on transdermal delivery of model macromolecules using hydrogel-forming microneedles: potential to enhance the administration of novel low molecular weight biotherapeutics. J. Mater. Chem. B (2020) doi:10.1039/D0TB00021C.
Schorer, M. et al. Rapid expansion of Treg cells protects from collateral colitis following a viral trigger. Nat Commun 11, 1–13 (2020).
González-Quilen, C. et al. Protective properties of grape-seed proanthocyanidins in human ex vivo acute colonic dysfunction induced by dextran sodium sulfate. Eur J Nutr (2020) doi:10.1007/s00394-020-02222-3.
Wang, Y. et al. Transport Mechanisms of Polymannuronic Acid and Polyguluronic Acid Across Caco-2 Cell Monolayers. Pharmaceutics 12, 167 (2020).
Pascual-Itoiz, M. A. et al. The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis. Sci Rep 10, 1–13 (2020).
Zhu, C., Mahesula, S., Temple, S. & Kokovay, E. Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche. Stem Cell Reports 12, 6–13 (2019).
Torge, A., Pavone, G., Jurisic, M., Lima-Engelmann, K. & Schneider, M. A comparison of spherical and cylindrical microparticles composed of nanoparticles for pulmonary application. Aerosol Science and Technology 53, 53–62 (2019).
Sankaran, J. et al. Single microcolony diffusion analysis in Pseudomonas aeruginosa biofilms. npj Biofilms Microbiomes 5, 1–10 (2019).
Rincel, M. et al. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (2019) doi:10.1007/s00213-019-05252-w.
Park, D. et al. Transdermal Drug Delivery Using a Specialized Cavitation Seed for Ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 66, 1057–1064 (2019).
Zhu, C., Mahesula, S., Temple, S. & Kokovay, E. Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche. Stem Cell Reports 12, 6–13 (2019).
Torge, A., Pavone, G., Jurisic, M., Lima-Engelmann, K. & Schneider, M. A comparison of spherical and cylindrical microparticles composed of nanoparticles for pulmonary application. Aerosol Science and Technology 53, 53–62 (2019).
Sankaran, J. et al. Single microcolony diffusion analysis in Pseudomonas aeruginosa biofilms. npj Biofilms Microbiomes 5, 1–10 (2019).
Rincel, M. et al. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (2019) doi:10.1007/s00213-019-05252-w.
Park, D. et al. Transdermal Drug Delivery Using a Specialized Cavitation Seed for Ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 66, 1057–1064 (2019).
Navarro, J., Swayambunathan, J., Lerman, M., Santoro, M. & Fisher, J. P. Development of keratin-based membranes for potential use in skin repair. Acta Biomaterialia 83, 177–188 (2019).
Lu, Y., Gao, X., Song, J., Chen, C.-T. A. & Chu, J. Colloidal toxic trace metals in urban riverine and estuarine waters of Yantai City, southern coast of North Yellow Sea. Science of The Total Environment 135265 (2019) doi:10.1016/j.scitotenv.2019.135265.
Karvinen, J., Ihalainen, T. O., Calejo, M. T., Jönkkäri, I. & Kellomäki, M. Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studies. Materials Science and Engineering: C 94, 1056–1066 (2019).
Hauth, J., Chodorski, J., Wirsen, A. & Ulber, R. Improved FRAP measurements on biofilms. bioRxiv 707950 (2019) doi:10.1101/707950.
Grenier, J. et al. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta Biomaterialia (2019) doi:10.1016/j.actbio.2019.05.070.
Friedrich, M. et al. HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation. Mucosal Immunology 12, 656 (2019).
Ehsanipour, A. et al. Injectable, Hyaluronic Acid-Based Scaffolds with Macroporous Architecture for Gene Delivery. Cel. Mol. Bioeng. (2019) doi:10.1007/s12195-019-00593-0.
Dobos, A. et al. Thiol–Gelatin–Norbornene Bioink for Laser-Based High-Definition Bioprinting. Advanced Healthcare Materials 0, 1900752 (2019).
Chen, Y., Zhang, M. & Ren, F. A Role of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis. Molecules 24, 513 (2019).
Ahn, J., Ryu, J., Song, G., Whang, M. & Kim, J. Network structure and enzymatic degradation of chitosan hydrogels determined by crosslinking methods. Carbohydrate Polymers 217, 160–167 (2019).
Zhang, K. et al. Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo. PLOS Pathogens 14, e1006925 (2018).
Van, C. S. et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314, H693–H703 (2018).
Sureda, E. A., Prykhodko, O. & Weström, B. Early effects on the intestinal barrier and pancreatic function after enteral stimulation with protease or kidney bean lectin in neonatal rats. British Journal of Nutrition 119, 992–1002 (2018).
Seitz, R. et al. Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature. Invest. Ophthalmol. Vis. Sci. 59, 2240–2251 (2018).
Rincel, M. et al. Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats. Brain Struct Funct 223, 883–895 (2018).
Landman, C. et al. Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota. PLOS ONE 13, e0202587 (2018).
Krug, S. M. et al. Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis. Mucosal Immunology 11, 345–356 (2018).
Hübner, K. et al. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nature Communications 9, 4860 (2018).
Gustafsson, S. et al. Blood-brain barrier integrity in a mouse model of Alzheimer’s disease with or without acute 3D6 immunotherapy. Neuropharmacology 143, 1–9 (2018).
Genser, L. et al. Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes. The Journal of Pathology 246, 217–230 (2018).
Dunn, K. W., Sutton, T. A. & Sandoval, R. M. Live-Animal Imaging of Renal Function by Multiphoton Microscopy. Current Protocols in Cytometry 83, 12.9.1-12.9.25 (2018).
das Graças C de Souza, M., Cyrino, F. Z., de Carvalho, J. J., Blanc-Guillemaud, V. & Bouskela, E. Protective Effects of Micronized Purified Flavonoid Fraction (MPFF) on a Novel Experimental Model of Chronic Venous Hypertension. European Journal of Vascular and Endovascular Surgery 55, 694–702 (2018).
Bücker, R. et al. Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon. Mucosal Immunol 11, 474–485 (2018).
Andreev-Andrievskiy, A. A., Popova, A. S., Lagereva, E. A. & Vinogradova, O. L. Fluid shift versus body size: changes of hematological parameters and body fluid volume in hindlimb-unloaded mice, rats and rabbits. J. Exp. Biol. 221, (2018).
Ahn, J., Ryu, J., Song, K. & Kim, J. Effects of Crosslinking Methods on Network Structure and Enzymatic Degradation of Methacrylate-Functionalized Chitosan Hydrogel. (2018) doi:10.26434/chemrxiv.7447490.v1.
Verhaegh, R., Petrat, F., Brencher, L., Kirsch, M. & de Groot, H. Autodigestion by migrated trypsin is a major factor in small intestinal ischemia-reperfusion injury. Journal of Surgical Research 219, 266–278 (2017).
Van Skike, C. E. et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. American Journal of Physiology-Heart and Circulatory Physiology 314, H693–H703 (2017).
Van Skike, C. E. et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. American Journal of Physiology-Heart and Circulatory Physiology 314, H693–H703 (2017).
Singh, P. et al. Neuropeptide Y regulates a vascular gateway for hematopoietic stem and progenitor cells. J Clin Invest 127, 4527–4540 (2017).
Schuetz, A., Radusheva, V., Krug, S. M. & Heinemann, U. Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization. Annals of the New York Academy of Sciences 1405, 147–159 (2017).
Schlecht, A. et al. Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization. The American Journal of Pathology 187, 2570–2589 (2017).
Sandoval, R. M. & Molitoris, B. A. Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology. Methods 128, 20–32 (2017).
Ranchoux, B. et al. Gut–Lung Connection in Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol 56, 402–405 (2017).
Propheter, D. C., Chara, A. L., Harris, T. A., Ruhn, K. A. & Hooper, L. V. Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc Natl Acad Sci U S A 114, 11027–11033 (2017).
Propheter, D. C., Chara, A. L., Harris, T. A., Ruhn, K. A. & Hooper, L. V. Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc. Natl. Acad. Sci. U.S.A. 114, 11027–11033 (2017).
Nultsch, K. & Germershaus, O. Silk fibroin degumming affects scaffold structure and release of macromolecular drugs. European Journal of Pharmaceutical Sciences 106, 254–261 (2017).
Nascimento, C. R. et al. Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease. Front. Immunol. 8, (2017).
McCurley, A. et al. Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. JASN 28, 1741–1752 (2017).
Li, B. et al. Development of Polymer Microcapsules Functionalized with Fucoidan to Target P-Selectin Overexpressed in Cardiovascular Diseases. Advanced Healthcare Materials 6, 1601200 (2017).
Lai De-Wei et al. TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy. Circulation Research 121, e37–e52 (2017).
Krug, S. M. et al. Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction. Journal of Controlled Release 260, 1–11 (2017).
Ilatovskaya, D. V., Palygin, O., Levchenko, V., Endres, B. T. & Staruschenko, A. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Scientific Reports 7, 299 (2017).
Epple, H.-J. et al. Architectural and functional alterations of the small intestinal mucosa in classical Whipple’s disease. Mucosal Immunology 10, 1542–1552 (2017).
Endres, B. T. et al. Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. American Journal of Physiology-Renal Physiology 313, F163–F173 (2017).
Dong, X. et al. Formulation and Drug Loading Features of Nano-Erythrocytes. Nanoscale Research Letters 12, 202 (2017).
Cording, J. et al. Trictide, a tricellulin-derived peptide to overcome cellular barriers. Annals of the New York Academy of Sciences 1405, 89–101 (2017).
Collett, J. A. et al. Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys. JASN 28, 2081–2092 (2017).
Bulant, C. A., Blanco, P. J., Müller, L. O., Scharfstein, J. & Svensjö, E. Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster. Microvascular Research 112, 53–64 (2017).
B. Guerzoni, L. P. et al. Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules. Biomaterials Science 5, 1549–1557 (2017).
Thakur, R. R. S. et al. Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv. and Transl. Res. 6, 800–815 (2016).
Soto, A. M. et al. Optical Projection Tomography Technique for Image Texture and Mass Transport Studies in Hydrogels Based on Gellan Gum. Langmuir 32, 5173–5182 (2016).
Pirozzi, C. et al. Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. The Journal of Nutritional Biochemistry 30, 108–115 (2016).
Misiorek, J. O. et al. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis 37, 777–786 (2016).
Marinval, N. et al. Identification of a Pro-Angiogenic Potential and Cellular Uptake Mechanism of a LMW Highly Sulfated Fraction of Fucoidan from Ascophyllum nodosum. Marine Drugs 14, 185 (2016).
Lee, S. et al. Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Scientific Reports 6, 26923 (2016).
Larrañeta, E. et al. A facile system to evaluate in vitro drug release from dissolving microneedle arrays. International Journal of Pharmaceutics 497, 62–69 (2016).
Dolowschiak, T. et al. IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection. Cell Host & Microbe 20, 238–249 (2016).
Clark Wooten, M. K., Koganti, V. R., Zhou, S., Rankin, S. E. & Knutson, B. L. Synthesis and Nanofiltration Membrane Performance of Oriented Mesoporous Silica Thin Films on Macroporous Supports. ACS Appl. Mater. Interfaces 8, 21806–21815 (2016).
Brauer, R. et al. MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunology 9, 974–985 (2016).
Voiniciuc, C. et al. MUCILAGE-RELATED10 Produces Galactoglucomannan That Maintains Pectin and Cellulose Architecture in Arabidopsis Seed Mucilage. Plant Physiol. 169, 403–420 (2015).
Souza, M. das G. C. de, Conde, C. M. S., Laflôr, C. M., Sicuro, F. L. & Bouskela, E. n-3 PUFA Induce Microvascular Protective Changes During Ischemia/Reperfusion. Lipids 50, 23–37 (2015).
Sand, E. et al. Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum. BMC Research Notes 8, 824 (2015).
Laudien, J. et al. Perfluorodecalin-Filled Poly(n-butyl-cyanoacrylate) Nanocapsules as Potential Artificial Oxygen Carriers: Preclinical Safety and Biocompatibility. J Nanosci Nanotechnol 15, 5637–5648 (2015).
Laffleur, F., Psenner, J. & Suchaoin, W. Permeation Enhancement via Thiolation: In Vitro and Ex Vivo Evaluation of Hyaluronic Acid–Cysteine Ethyl Ester. Journal of Pharmaceutical Sciences 104, 2153–2160 (2015).
Huang, H. et al. Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition. Diabetes 64, 200–212 (2015).
Gouyer, V. et al. Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier. Scientific Reports 5, 9577 (2015).
Ferrell, N. et al. Shear stress is normalized in glomerular capillaries following ⅚ nephrectomy. American Journal of Physiology-Renal Physiology 308, F588–F593 (2015).
Dünnhaupt, S. et al. Thiolated nanocarriers for oral delivery of hydrophilic macromolecular drugs. Carbohydrate Polymers 117, 577–584 (2015).
Davis, M. J. et al. Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence. The Journal of Immunology 194, 2219–2231 (2015).
Chen, L., An, H. Z. & Doyle, P. S. Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates. Langmuir 31, 9228–9235 (2015).
Braunger, B. M. et al. Deletion of Ocular Transforming Growth Factor β Signaling Mimics Essential Characteristics of Diabetic Retinopathy. The American Journal of Pathology 185, 1749–1768 (2015).
Zeilbeck, L. F., Müller, B., Knobloch, V., Tamm, E. R. & Ohlmann, A. Differential Angiogenic Properties of Lithium Chloride In Vitro and In Vivo. PLOS ONE 9, e95546 (2014).
Vagenende, V., Ching, T.-J., Chua, R.-J., Jiang, Q. Z. & Gagnon, P. Self-assembly of lipopolysaccharide layers on allantoin crystals. Colloids and Surfaces B: Biointerfaces 120, 8–14 (2014).
Svensjö, E., Nogueira de Almeida, L., Vellasco, L., Juliano, L. & Scharfstein, J. Ecotin-Like ISP of L. major Promastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2 and B1 Receptors. Mediators of Inflammation https://www.hindawi.com/journals/mi/2014/143450/abs/ (2014) doi:10.1155/2014/143450.
Stewart, S. E. et al. The perforin pore facilitates the delivery of cationic cargos. J. Biol. Chem. 289, 9172–9181 (2014).
Spasojevic, M. et al. Reduction of the Inflammatory Responses against Alginate-Poly-L-Lysine Microcapsules by Anti-Biofouling Surfaces of PEG-b-PLL Diblock Copolymers. PLOS ONE 9, e109837 (2014).
Sommer, J. et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. International Journal of Molecular Medicine 34, 651–660 (2014).
Sommer, F. et al. Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture. PLOS ONE 9, e85254 (2014).
Schmitz, V. et al. C5a and Bradykinin Receptor Cross-Talk Regulates Innate and Adaptive Immunity in Trypanosoma cruzi Infection. The Journal of Immunology 193, 3613–3623 (2014).
Richter, J. F. et al. Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon. British Journal of Nutrition 111, 1040–1049 (2014).
Mattace Raso, G. et al. Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. The Journal of Nutritional Biochemistry 25, 81–90 (2014).
Lockett, A. D. et al. Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium. PLOS ONE 9, e93979 (2014).
Hauptstein, S., Bonengel, S., Griessinger, J. & Bernkop-Schnürch, A. Synthesis and Characterization of pH Tolerant and Mucoadhesive (Thiol–Polyethylene Glycol) Chitosan Graft Polymer for Drug Delivery. Journal of Pharmaceutical Sciences 103, 594–601 (2014).
Cheng, C., Teasdale, I. & Brüggemann, O. Stimuli-Responsive Capsules Prepared from Regenerated Silk Fibroin Microspheres. Macromolecular Bioscience 14, 807–816 (2014).
Brown, M. B. et al. Loss of Cystic Fibrosis Transmembrane Conductance Regulator Impairs Lung Endothelial Cell Barrier Function and Increases Susceptibility to Microvascular Damage from Cigarette Smoke. Pulm Circ 4, 260–268 (2014).
Bojko, A., Andreatta, G., Montagne, F., Renaud, P. & Pugin, R. Fabrication of thermo-responsive nano-valve by grafting-to in melt of poly(N-isopropylacrylamide) onto nanoporous silicon nitride membranes. Journal of Membrane Science 468, 118–125 (2014).
Boa, B. C. S. et al. Chronic Aerobic Exercise Associated to Dietary Modification Improve Endothelial Function and eNOS Expression in High Fat Fed Hamsters. PLoS ONE 9, e102554 (2014).
Boa, B. C. S. et al. Chronic Aerobic Exercise Associated to Dietary Modification Improve Endothelial Function and eNOS Expression in High Fat Fed Hamsters. PLOS ONE 9, e102554 (2014).
Yang, D., Moran‐Mirabal, J. M., Parlange, J.-Y. & Walker, L. P. Investigation of the porous structure of cellulosic substrates through confocal laser scanning microscopy. Biotechnology and Bioengineering 110, 2836–2845 (2013).
Wagner, A. E. et al. DSS-induced acute colitis in C57BL/6 mice is mitigated by sulforaphane pre-treatment. The Journal of Nutritional Biochemistry 24, 2085–2091 (2013).
Trongsatitkul, T. & Budhlall, B. M. Microgels or microcapsules? Role of morphology on the release kinetics of thermoresponsive PNIPAm-co-PEGMa hydrogels. Polym. Chem. 4, 1502–1516 (2013).
Tanaka, T. et al. Dynamic analysis of lung metastasis by mouse osteosarcoma LM8: VEGF is a candidate for anti-metastasis therapy. Clin Exp Metastasis 30, 369–379 (2013).
Silva, J. V. C., Peixoto, P. D. S., Lortal, S. & Floury, J. Transport phenomena in a model cheese: The influence of the charge and shape of solutes on diffusion. Journal of Dairy Science 96, 6186–6198 (2013).
Sedhom, M. A. K. et al. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut 62, 1714–1723 (2013).
Schmitz‐Hertzberg, S.-T., Mak, W. C., Lai, K. K., Teller, C. & Bier, F. F. Multifactorial design of poly(d,l-lactic-co-glycolic acid) capsules with various release properties for differently sized filling agents. Journal of Applied Polymer Science 130, 4219–4228 (2013).
Schmidt, C. et al. Confocal laser endomicroscopy reliably detects sepsis-related and treatment-associated changes in intestinal mucosal microcirculation. Br J Anaesth 111, 996–1003 (2013).
Ranganathan, P., Jayakumar, C., Santhakumar, M. & Ramesh, G. Netrin-1 regulates colon-kidney cross talk through suppression of IL-6 function in a mouse model of DSS-colitis. Am J Physiol Renal Physiol 304, F1187–F1197 (2013).
Müller, C., Ma, B. N., Gust, R. & Bernkop-Schnürch, A. Thiopyrazole preactivated chitosan: Combining mucoadhesion and drug delivery. Acta Biomaterialia 9, 6585–6593 (2013).
Melican, K., Veloso, P. M., Martin, T., Bruneval, P. & Duménil, G. Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model. PLOS Pathogens 9, e1003139 (2013).
Meier, T. O. et al. Increased Permeability of Cutaneous Lymphatic Capillaries and Enhanced Blood Flow in Psoriatic Plaques. DRM 227, 118–125 (2013).
Kojima, T. & Takayama, S. Microscale Determination of Aqueous Two Phase System Binodals by Droplet Dehydration in Oil. Anal. Chem. 85, 5213–5218 (2013).
Corridon, P. R. et al. A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors. American Journal of Physiology-Renal Physiology 304, F1217–F1229 (2013).
Beloqui, A. et al. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. International Journal of Pharmaceutics 454, 775–783 (2013).
Xu, C., Shen, Y., Littman, D. R., Dustin, M. L. & Velázquez, P. Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. Journal of Leukocyte Biology 92, 413–419 (2012).
Svensjö, E. et al. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1–CXCR1/2-pathway. Microvascular Research 83, 185–193 (2012).
Srikantha, N. et al. Influence of molecular shape, conformability, net surface charge, and tissue interaction on transscleral macromolecular diffusion. Exp. Eye Res. 102, 85–92 (2012).
Sandoval, R. M. et al. Multiple Factors Influence Glomerular Albumin Permeability in Rats. JASN 23, 447–457 (2012).
Müller, C. et al. Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications. J Nanopart Res 15, 1353 (2012).
Montagne, F., Blondiaux, N., Bojko, A. & Pugin, R. Molecular transport through nanoporous silicon nitride membranes produced from self-assembling block copolymers. Nanoscale 4, 5880–5886 (2012).
Choi, N. W. et al. Multiplexed Detection of mRNA Using Porosity-Tuned Hydrogel Microparticles. Anal. Chem. 84, 9370–9378 (2012).
Bowie, R. V. et al. Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier. American Journal of Physiology-Gastrointestinal and Liver Physiology 302, G781–G793 (2012).
Barbosa, M. do C. L. et al. Effects of babassu nut oil on ischemia/reperfusion-induced leukocyte adhesion and macromolecular leakage in the microcirculation: Observation in the hamster cheek pouch. Lipids in Health and Disease 11, 158 (2012).
Axelsson, J., Öberg, C. M., Rippe, A., Krause, B. & Rippe, B. Size-selectivity of a synthetic high-flux and a high cut-off dialyzing membrane compared to that of the rat glomerular filtration barrier. Journal of Membrane Science 413–414, 29–37 (2012).
Silva, J. F. R., Cyrino, F. Z. G. A., Breitenbach, M. M. D., Bouskela, E. & Carvalho, J. J. Vimentin and laminin are altered on cheek pouch microvessels of streptozotocin-induced diabetic hamsters. Clinics 66, 1961–1968 (2011).
Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. PNAS 108, 9601–9606 (2011).
Meier, T. O. et al. Microvascular regeneration in meshed skin transplants after severe burns. Burns 37, 1010–1014 (2011).
Chalaris, A. et al. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. Journal of Experimental Medicine 207, 1617–1624 (2010).
Svensjö, E. et al. Salivary Gland Homogenates of Lutzomyia longipalpis and Its Vasodilatory Peptide Maxadilan Cause Plasma Leakage via PAC1 Receptor Activation. JVR 46, 435–446 (2009).
Monteiro, A. C. et al. Kinin Danger Signals Proteolytically Released by Gingipain Induce Fimbriae-Specific IFN-γ- and IL-17-Producing T Cells in Mice Infected Intramucosally with Porphyromonas gingivalis. The Journal of Immunology 183, 3700–3711 (2009).
Hombach, J. & Bernkop-Schnürch, A. Chitosan solutions and particles: Evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model. International Journal of Pharmaceutics 376, 104–109 (2009).
Van Crombruggen, K. et al. Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis. European Journal of Pharmacology 579, 337–349 (2008).
Delius, S. et al. Transgastric in vivo histology in the peritoneal cavity using miniprobe-based confocal fluorescence microscopy in an acute porcine model. Endoscopy 39, 407–411 (2007).
Asgeirsson, D., Venturoli, D., Fries, E., Rippe, B. & Rippe, C. Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation. Acta Physiologica 191, 237–246 (2007).
Harinarayan, C. et al. An exclusion mechanism in ion exchange chromatography. Biotechnology and Bioengineering 95, 775–787 (2006).
Erichsen, K. et al. Low-Dose Oral Ferrous Fumarate Aggravated Intestinal Inflammation in Rats With Dss-Induced Colitis. Inflamm Bowel Dis 11, 744–748 (2005).
Mulherkar, P. & van Reis, R. Flex test: a fluorescent dextran test for UF membrane characterization. Journal of Membrane Science 236, 171–182 (2004).
Ten Hove, T., Drillenburg, P., Wijnholds, J., te Velde, A. A. & van Deventer, S. J. H. Differential Susceptibility of Multidrug Resistance Protein-1 Deficient Mice to DSS and TNBS-Induced Colitis. Dig Dis Sci 47, 2056–2063 (2002).
Simões, C., Svensjö, E. & Bouskela, E. Effects of Cromakalim and Glibenclamide on Arteriolar and Venular Diameters and Macromolecular Leakage in the Microcirculation During Ischemia/Reperfusion. Journal of Cardiovascular Pharmacology 39, 340 (2002).
Simões, C., Svensjö, E. & Bouskela, E. Effects of l-NA and Sodium Nitroprusside on Ischemia/Reperfusion-Induced Leukocyte Adhesion and Macromolecular Leakage in Hamster Cheek Pouch Venules. Microvascular Research 62, 128–135 (2001).
Conde, C. M. S., Albano, F., Bouskela, E., Felzenszwalb, I. & Svensjö, E. Inhibition of ischemia/reperfusion induced plasma leakage by α-tocopherol, trolox, and a shark cartilage preparation with anti-oxidant properties. Nutrition Research 21, 1363–1371 (2001).

Specifications

FITC-dextran 4
FITC-dextran 10
FITC-dextran 20
FITC-dextran 40
FITC-dextran 70
FITC-dextran 110
FITC-dextran 150
FITC-dextran 500
FITC-dextran 1000
FITC-dextran 2000

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Wako cytiva GE Bethyl Harlan Bio-serv 修饰性PEG

TDB–FITC-dextran

FITC -dextran

Specifications