TORPAC 大鼠・豚鼠投药用胶囊及其配套工具使用说明书
TORPAC投药用胶囊代理
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各种各样的被验药物需要经口投药的情况下，使用胶囊会比其他方法来的更为合适与便利。
- 粉末或者固体的药物，或者无法用导管进行投药的情况下，使用胶囊就可以轻松投药。
- 对应一些有臭味或者苦味的药剂，能够简单投药，减轻动物的痛苦。
- 个别制剂类药物的投药相当便利。
- 为了能够长时间持续的发挥药效，胶囊可以辅助充分吸收。
- 实验规程中必须要用胶囊进行投药的情况下，是最适合的。
- 与药物混在饲料中进行喂食相比，用胶囊的方法更精准且无残留。
| 胶囊尺寸 | Size 9 Capsule | Size 9el Capsule |
| 填充容量 | 0.025ml | 0.08ml |
| 填充重量 | 25mg* | 80mg* |
| 长度（密闭时） | 8.6mm | 23.2mm |
| 最大外径 | 2.65mm | 2.65mm |
| 动物体重 | 大鼠 200g 以上 豚鼠 300g 以上 |
大鼠 200g 以上 豚鼠 300g 以上 |
*：填充物密度为1g/ml时。
Capsule Filling Funnel
Fast, Accurate & Easy! Ideal For Research Studies
Fast & accurate way to fill capsules without spillage.
Use Tamper for higher fill weights.
Stainless Steel (highly polished) for high GMP
and easy cleanup.
Lightweight for use on analytical balances.
Available in Sizes 000 through 5, 00el, 0el; for
rats 9, 9el; and, for veterinary use 11 and 12/13.
* Free Capsules offer for sizes 000-5
快速准确的方法填充胶囊没有溢出。
使用捣固较高的填充重量。
不锈钢(高度抛光)，高GMP
而且很容易清理。
重量轻，用于分析天平。
可提供尺寸从000到500el, 0el;为
大鼠9,9el;以及，兽医使用11和12/13。
Capsule Dosing the Rat
Torpac’s size 9 empty gelatin capsules provide a convenient method for orally dosing
laboratory rats 200 gm+ (150 gm minimum) using a dosing syringe. Dosing with capsules is an excellent alternative when you cannot gavage.
Before beginning your study become comfortable dosing a rat. First practice dosing
using a gavage needle. Next, practice using empty capsules in the dosing syringe.
Pre-condition the animals by giving 3 doses of saline solution each day for 3 days followed by administering an empty capsule each day for 3 days using the dosing syringe for capsules.
The following instructions include images
from the included CD-ROM.
给大鼠注射胶囊
Torpac的9号空明胶胶囊提供了一种方便的口服给药方法
实验室大鼠200克以上(最少150克)，使用给药注射器。当你不能灌胃时，服用胶囊是一个很好的选择。
在开始你的研究之前，先给大鼠服药。第一次练习给药
使用灌胃针。接下来，练习在给药注射器中使用空胶囊。
通过每天给动物3次盐水溶液，连续3天，然后使用胶囊给药注射器每天给动物服用空胶囊，连续3天。
下面的说明包括图像
- If you prefer working with a
curved dosing syringe, bend the shaft in a gentle curve (see the video “Dosing Tips” for a demonstration). In brief, keep the plunger in the shaft and bend all along the length of the shaft and not just at one point to avoid cracking the shaft.
Before inserting the syringe put it next to the rat with the capsule holder section over the stomach area and the syringe near the mouth. Note the length of syringe that extends beyond the mouth. During Step 6 this should be the position of the syringe when the capsule is ejected.
弯曲剂量注射器，弯曲轴在一个温和的曲线(见视频“剂量提示”演示)。简而言之，要保持柱塞在轴上，并沿着轴的长度弯曲，而不是仅仅在一点上弯曲，以避免轴开裂。
在插入注射器之前，将其放在大鼠旁边，胶囊支架部分位于胃区域上方，注射器靠近口腔。注意注射器在口腔外的长度。在第6步中，这应该是胶囊喷射时注射器的位置。
- Insert the filled capsule, body (longer and narrower piece) first, into the syringe’s capsule holding cup. A small portion of the capsule’s cap dome will protrude from the cup.
Lubricate the tip of the capsule and the syringe with Vaseline or Glycerin. This makes administration easier and protects the capsule from premature softening by saliva during administration. This also prevents any loose capsules from prematurely falling out of the syringe.
首先将填满的胶囊(较长和较窄的部分)插入注射器的胶囊杯中。胶囊的一小部分盖子圆顶将从杯口突出。
用凡士林或甘油润滑胶囊尖端和注射器。这使得管理更容易，并保护胶囊过早软化的唾液在管理期间。这也可以防止任何松散的胶囊过早地从注射器中掉出来。
- As shown in the video, restrain the rat by grasping the scruff of the neck with one hand and the rear with the other hand
如视频所示，用一只手抓住老鼠的颈背，另一只手抓住老鼠的屁股
- Wrap the rat’s tail around your small finger to secure the lower portion of the rat.
将老鼠的尾巴缠绕在你的小手指上，以固定老鼠的下部。
- Place the tip of the syringe in the center of the mouth and follow the roof of the mouth to the opening of the esophagus. When you feel resistance go slowly until the rat swallows the capsule holder section (the widest part). Tilt the rat’s head back with the shaft of the syringe. This straightens the esophagus and makes insertion of the syringe easier.
将注射器的尖端放在口腔中心，顺着口腔顶部到达食道口。当你感到有阻力时，慢慢地走，直到大鼠吞下胶囊持有者的部分(最宽的部分)。用注射器的轴将大鼠的头向后倾斜。这使食道变直，使注射器的插入更容易。
NOTE: Once the syringe has passed the back of the mouth, if you feel any ‘ridges’ you may have entered the trachea. If this happens, slowly remove the syringe. Do NOT eject the capsule.
注意:一旦注射器经过口腔后部，如果你感觉有任何“隆起”，你可能已经进入气管。如果发生这种情况，慢慢取出注射器。不要弹射胶囊。
- The time from initial insertion to swallowing of the syringe should take 15-20 seconds. If excess time is taken the capsule may soften due to contact with saliva. Once the rat swallows the capsule holder continue at normal speed moving the syringe down the esophagus with gentle pressure. For a 200-250gm rat 10 cm of the syringe should be inserted past the incisor teeth. Adjust the insertion depth based on the rat’s size.
NOTE: Do not force the syringe.
从最初插入到吞下注射器需要15-20秒的时间。如果服用时间过长，胶囊可能会因与唾液接触而软化。一旦大鼠吞下胶囊架继续以正常速度移动注射器沿着食道与温和的压力。对于200-250克大鼠，应将10厘米的注射器插入门牙。根据大鼠大小调整插入深度。
注意:不要用力注射。
- The radiograph above shows the correct placement of the syringe and ejection of a barium filled capsule into the bottom of the esophagus (the black arrow is pointing to the capsule).
上面的x光片显示了注射器的正确位置和充满钡的胶囊射入食管底部(黑色箭头指向胶囊)。
- Now eject the capsule by pushing the syringe’s plunger. Remove the syringe from the stomach but slow down when the capsule holder section is being withdrawn through the esophagus and mouth.
If there is a concern that the capsule was ejected in the esophagus and not in the stomach, close the rat’s mouth and gently stroke the neck to facilitate swallowing. A gavage of a few ml of saline solution or water will facilitate movement of the capsule into the stomach.
现在通过推动注射器的柱塞来弹出胶囊。从胃中取出注射器，但当胶囊夹部分从食道和口腔中取出时，要放慢速度。
如果担心胶囊是在食道而不是在胃里喷出的，可以闭上大鼠的嘴，轻轻抚摸脖子，以方便吞咽。灌入几毫升盐水或水将促进胶囊进入胃。
- Tips: When dosing additional rats with the same syringe dry the capsule holder section with an absorbent tissue to prevent the next capsule from sticking in the capsule holder. If capsules soften during administration and cannot use Vaseline or Glycerin as suggested in Step 2, consider freezing (or cooling to 5C) prior to administering them
提示:当用相同的注射器给更多的大鼠注射时，用吸收性组织擦干胶囊架部分，以防止下一个胶囊粘在胶囊架上。
如果胶囊在给药过程中软化，不能使用步骤2中建议的凡士林或甘油，在给药前考虑冷冻(或冷却至5C)